Mingyang Song, MD, ScD
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Mingyang Song, MBBS, ScD iis an Associate Professor of Medicine in the CTEU at MGH and an Associate Professor of Clinical Epidemiology and Nutrition in the Departments of Epidemiology and Nutrition at Harvard T.H. Chan School of Public Health. Dr. Song’s work aims to translate epidemiologic advances into the clinic for improved cancer care and has two main themes: (1) integrating large-scale observational studies with biomarker-based clinical trials to identify novel nutritional and gut microbiota-targeted strategies for cancer prevention and treatment; (2) integrating electronic health record data with molecular profiling for precision colonoscopy screening and surveillance. Dr. Song is currently a Statistics Associate Editor of Gut, an Associate Editor of Journal of the National Cancer Institute (JNCI), and an Editor of European Journal of Epidemiology.
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Projects
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Coffee and metabolites modulating the gut microbiome for improved colorectal cancer survival
Supported by a NIH R01 grant, we are determining the mechanistic effect of coffee on improved colorectal cancer survival and to identify coffee-related metabolites and microbial features that may mediate this effect. As part of the project, we are conducting a randomized controlled trial of coffee intake among patients with colon cancer at the MGH Cancer Center.
The gut microbiome, lifestyle, and colorectal neoplasia
Supported by a NIH U01 grant, we are prospectively characterizing the interplay between the gut microbiome and dietary and lifestyle factors in colorectal neoplasia using an multi’omics approach by leveraging the large-scale stool collection in the Nurses’ Health Study 2 and Southern Community Cohort Study.
DNA methylation in peripheral blood for improved colorectal cancer prevention
Supported by a NIH R01 grant, we are conducting the largest prospective study to date to characterize the landscape of genome-wide DNA methylation markers associated with colorectal cancer and examine the biological relevance and modifiable potential of DNA methylation for colorectal cancer prevention.
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Key Publications
Wang K, Lo CH, Mehta RS, Nguyen LH, Wang Y, Ma W, Ugai T, Kawamura H, Ugai S, Takashima Y, Mima K, Arima K, Okadome K, Giannakis M, Sears CL, Meyerhardt JA, Ng K, Segata N, Izard J, Rimm EB, Garrett WS, Huttenhower C, Giovannucci EL, Chan AT, Ogino S, Son
Song M, Wu K, Meyerhardt JA, Ogino S, Wang M, Fuchs CS, Giovannucci EL, Chan AT. Fiber intake and survival after colorectal cancer diagnosis. JAMA Oncol. 2018 Jan 1;4(1):71-79.
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